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KMID : 0384119930130010151
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 1 p.151 ~ p.158
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Evaluation of Donor Blood for Anti-HBc and HBV DNA and Its Clinical Significance
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Abstract
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The value of anti-HBc test for the prevention of transfusion-transmitted hepatitis has apparently been validated on the basis of the retrospective evaluation of the relationship between anti-HBc & other markers. In association with the prevention
of
transfusion associated viral hepatitis, we investigated the prevalence for HBsAg, anti-HBs, anti-HBc, HBV DNA and anti-HCV in 200 volunteer blood donors. The mean age of the blood donors was 25 years and male to female sex ratio was 6.7 : 1. The
HBsAg
positive rate was 3.0%. The proportion of donors who were negative for HBsAg and positive for anti-HBc was 35.5%. Among them the rate of donors positive for anti-HBs was 23.5% and the remainder(12.0%) were only positive for anti-HBc. HBV DNA was
detected in 6 cases(6.7%) of 90 selected donors. Three cases of them were positive for HBsAg. Among the 3 cases of HBV DNA positive donors negative for HBsAg, 2 cases were positive for anti-HBc and have abnormally elevated ALT and l case didn't
show any
anormal serologic markers but abnormal ALT. Among the 8 cases who showed the positivity only for anti-HBc and abnormal ALT, 4 cases(50%) were positive for HBV DNA and l case(12.5%) was positive for anti-HCV. Anti-HCV was detected only in l
case(0.5%) of
200 blood donors and the blood was also positive for anti-HBc. The serum level of ALT was 56 IU/L. In conclusion, the screening of blood donors for anti-HBc & ALT are necessary for the prevention of post-transfusion hepatitis. When a blood donor
shows
and elevated level of ALT and the presence of anti-HBc, further tests employing the HBV DNA or PCR should be done to prevent transfusion-associated HBV or HCV infections.
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KEYWORD
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